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Teens and Antidepressants: The Case for Holistic Treatment

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Teen depression is on the rise. Parents and doctors need solutions. No one wants to see a child or adolescent suffer. And medication may seem like the easiest and quickest way to treat depressed or suicidal teens.

In some cases, antidepressants are a necessary tool. They address the physical and mental health of a teenager. This is particularly true if a teen is considering self-harm. However, it’s important to understand how teenage antidepressants change the brain. Moreover, parents need to know about the side effects. In addition, the long-term impact of antidepressants on adolescents can be negative as they mature.

How Antidepressants Work

To some extent, depression and its effects on the brain are a mystery. In addition, experts are not entirely sure what causes depression. Furthermore, they are not completely clear on how antidepressants help.

The simplest explanation is that antidepressants impact the behavior of brain chemicals called neurotransmitters. These neurotransmitters are released to send messages between nerve cells. Specifically, the neurotransmitters that impact depression are serotonin, dopamine, and norepinephrine.

The most prescribed antidepressants are reuptake inhibitors. These medications for teenage depression prevent neurotransmitters from being absorbed back into the nerve cells in the brain. The theory is that keeping levels of the neurotransmitters higher could improve communication between the nerve cells. Thus, the circuits in the brain that regulate mood are stronger.

Newport Academy Treatment Resources Teens Antidepressants Facts

Common Antidepressants for Teens

Different kinds of depression medications target different neurotransmitters. The three main types of reuptake inhibitors are:

  • Selective serotonin reuptake inhibitors (SSRIs): SSRIs affect serotonin transporters and include Celexa, Lexapro, Luvox, Paxil, Prozac, Zoloft, Abilify, and Seroquel.
  • Serotonin and norepinephrine reuptake inhibitors (SNRIs): SNRIs block the reuptake of both serotonin and norepinephrine; they include Cymbalta, Effexor, Khedezla, Fetzima, and Pristiq.
  • Norepinephrine and dopamine reuptake inhibitors (NDRIs): NDRIs affect the reuptake of both norepinephrine and dopamine. Wellbutrin is the drug that represents this category.

Other types of medication for teenage anxiety and depression work in different ways. Tetracylics, such as Asendin, Remeron, and Ludiomil, stop neurotransmitters from binding with nerve receptors. Additionally, serotonin antagonist and reuptake inhibitors redirect serotonin particles to more beneficial receptors.

How Effective Are Antidepressants?

Do antidepressants work? There is evidence on both sides of the argument.

In a 2008 study led by Irving Kirsch of Harvard Medical School, researchers looked at 35 different antidepressant drug trials submitted to the FDA. This was for the licensing of Prozac, Effexor, Serzone, and Paxil. They found that the effect of these antidepressants was not much greater than the effect of a placebo drug. Overall, the study showed that placebos were 82 percent as effective as the antidepressants.

According to Kirsch, “Analyses of the published data and the unpublished data that were hidden by the drug companies reveal that most (if not all) of the benefits are due to the placebo effect.”

The results of Kirsch’s study were confirmed by the findings of a 2010 study in the Journal of the American Medical Association. Hence, this study found that antidepressants had a benefit only for people with severe depression. Antidepressants for teens may not be as effective for those suffering from mild to moderate varieties of the disorder.

Statistics on Antidepressants

In 2012, Kirsch conducted another study on antidepressants. This one found that the combination of psychotherapy and antidepressants might be slighter more beneficial than antidepressants alone or psychotherapy alone. Furthermore, the study suggested that antidepressants and psychotherapy had a similar effect as alternative therapies for depression.

The Treatment for Adolescents with Depression Study, funded by the National Institute of Mental Health, also looked at the efficacy of teen antidepressants. Results indicated that a combination of medication and psychotherapy is effective treatment for adolescents with depression.

Clearly, the research on this topic is contradictory. Therefore, it reveals how much is unknown about the effectiveness of depression medication for children.

Side Effects of Antidepressants

Even when antidepressants seem to relieve symptoms of depression, they have many undesirable side effects. In addition, these side effects can be dangerous and even life threatening. Side effects of Prozac in children and teens as well as for other antidepressants include the following:

  • Increases in suicidal ideation among children and young adults
  • Long-term weight gain
  • Insomnia
  • Nausea and diarrhea
  • Sexual dysfunction, which affects 70 to 80 percent of people on SSRIs
  • Increased risk of stroke and death among older adults
  • Greater risk of relapse after recovery.

When it comes to teenagers and antidepressants, parents need to look at the long-term health effects. In addition, new discoveries are being made about these side effects.

Recently, a study found evidence that long-term antidepressant use may be associated with increased risk of type-2 diabetes for young adults.

Furthermore, data indicates that antidepressant medication may double the risk of suicide and aggressive behavior in teens and children under 18.

Antidepressants Impact the Brain

Furthermore, antidepressants create dramatic changes in the brain immediately. Specifically, changes in the functional structure of the brain have been observed after a single dose of SSRI medication. Therefore, this is significant because the teenage brain is still developing. In fact, the brain does not fully mature until a person’s mid-20s.

“When different treatments are equally effective, choice should be based on risk and harm, and of all of these treatments, antidepressant drugs are the riskiest and most harmful. If they are to be used at all, it should be as a last resort, when depression is extremely severe and all other treatment alternatives have been tried and failed.”

—Dr. Irving Kirsch, Harvard Medical School

Alternatives to Antidepressants

Medication is not the only approach for addressing teen depression. In fact, studies show that clinical and holistic methods for decreasing teen anxiety and depression can be equally or more effective than prescription medication.

Clinical therapy modalities: Cognitive Behavioral Therapy, Dialectical Behavioral Therapy, and interpersonal psychotherapy are proven to be effective in treating depression in adolescents.

Exercise: In one study, 30 minutes of exercise three times per week was as effective as drugs for depression.

Nutrition: Diet can be a powerful method for relieving teen depression. In a study known as the SMILES Trial (Supporting the Modification of Lifestyle in Lowered Emotional States), one-third of participants experienced remission from depressive symptoms after three months of a healthy diet.

Mindfulness practice: A review study at Johns Hopkins found that meditation is just as effective as medication for teenage anxiety and depression.

In conclusion, teenagers and antidepressants might not be a healthy mix. Hence, before parents fill prescriptions for Zoloft for teens or Prozac for teens, they need to explore the full range of treatment options.


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